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Vitamin D Insufficiency and Deficiency and Mortality from Respiratory Diseases in a Cohort of Older Adults: Potential for Limiting the Death Toll during and beyond the COVID-19 Pandemic?

Identifieur interne : 000074 ( Main/Exploration ); précédent : 000073; suivant : 000075

Vitamin D Insufficiency and Deficiency and Mortality from Respiratory Diseases in a Cohort of Older Adults: Potential for Limiting the Death Toll during and beyond the COVID-19 Pandemic?

Auteurs : Hermann Brenner [Allemagne] ; Bernd Holleczek [Allemagne] ; Ben Schöttker [Allemagne]

Source :

RBID : pubmed:32824839

Descripteurs français

English descriptors

Abstract

The COVID-19 pandemic goes along with increased mortality from acute respiratory disease. It has been suggested that vitamin D3 supplementation might help to reduce respiratory disease mortality. We assessed the prevalence of vitamin D insufficiency and deficiency, defined by 25-hydroxyvitamin D (25(OH)D) blood levels of 30-50 and <30 nmol/L, respectively, and their association with mortality from respiratory diseases during 15 years of follow-up in a cohort of 9548 adults aged 50-75 years from Saarland, Germany. Vitamin D insufficiency and deficiency were common (44% and 15%, respectively). Compared to those with sufficient vitamin D status, participants with vitamin D insufficiency and deficiency had strongly increased respiratory mortality, with adjusted hazard ratios (95% confidence intervals) of 2.1 (1.3-3.2) and 3.0 (1.8-5.2) overall, 4.3 (1.3-14.4) and 8.5 (2.4-30.1) among women, and 1.9 (1.1-3.2) and 2.3 (1.1-4.4) among men. Overall, 41% (95% confidence interval: 20-58%) of respiratory disease mortality was statistically attributable to vitamin D insufficiency or deficiency. Vitamin D insufficiency and deficiency are common and account for a large proportion of respiratory disease mortality in older adults, supporting the hypothesis that vitamin D3 supplementation could be helpful to limit the burden of the COVID-19 pandemic, particularly among women.

DOI: 10.3390/nu12082488
PubMed: 32824839
PubMed Central: PMC7468980


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<term>Cohort Studies (MeSH)</term>
<term>Coronavirus Infections (blood)</term>
<term>Coronavirus Infections (complications)</term>
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<term>Pneumonia, Viral (mortality)</term>
<term>Prevalence (MeSH)</term>
<term>Proportional Hazards Models (MeSH)</term>
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<term>Respiratory Tract Diseases (complications)</term>
<term>Respiratory Tract Diseases (mortality)</term>
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<term>Pneumopathie virale (mortalité)</term>
<term>Pneumopathie virale (sang)</term>
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<term>Sujet âgé (MeSH)</term>
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<term>Vitamine D (sang)</term>
<term>Vitamines (administration et posologie)</term>
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<term>Vitamins</term>
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<term>Vitamin D Deficiency</term>
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<term>Pneumonia, Viral</term>
<term>Respiratory Tract Diseases</term>
<term>Vitamin D Deficiency</term>
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<term>Infections à coronavirus</term>
<term>Maladies de l'appareil respiratoire</term>
<term>Pneumopathie virale</term>
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<term>Carence en vitamine D</term>
<term>Infections à coronavirus</term>
<term>Maladies de l'appareil respiratoire</term>
<term>Pneumopathie virale</term>
<term>Vitamine D</term>
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<term>Carence en vitamine D</term>
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<term>Allemagne</term>
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<term>Aged</term>
<term>Betacoronavirus</term>
<term>Cohort Studies</term>
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<front>
<div type="abstract" xml:lang="en">The COVID-19 pandemic goes along with increased mortality from acute respiratory disease. It has been suggested that vitamin D
<sub>3</sub>
supplementation might help to reduce respiratory disease mortality. We assessed the prevalence of vitamin D insufficiency and deficiency, defined by 25-hydroxyvitamin D (25(OH)D) blood levels of 30-50 and <30 nmol/L, respectively, and their association with mortality from respiratory diseases during 15 years of follow-up in a cohort of 9548 adults aged 50-75 years from Saarland, Germany. Vitamin D insufficiency and deficiency were common (44% and 15%, respectively). Compared to those with sufficient vitamin D status, participants with vitamin D insufficiency and deficiency had strongly increased respiratory mortality, with adjusted hazard ratios (95% confidence intervals) of 2.1 (1.3-3.2) and 3.0 (1.8-5.2) overall, 4.3 (1.3-14.4) and 8.5 (2.4-30.1) among women, and 1.9 (1.1-3.2) and 2.3 (1.1-4.4) among men. Overall, 41% (95% confidence interval: 20-58%) of respiratory disease mortality was statistically attributable to vitamin D insufficiency or deficiency. Vitamin D insufficiency and deficiency are common and account for a large proportion of respiratory disease mortality in older adults, supporting the hypothesis that vitamin D
<sub>3</sub>
supplementation could be helpful to limit the burden of the COVID-19 pandemic, particularly among women.</div>
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<ArticleTitle>Vitamin D Insufficiency and Deficiency and Mortality from Respiratory Diseases in a Cohort of Older Adults: Potential for Limiting the Death Toll during and beyond the COVID-19 Pandemic?</ArticleTitle>
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<Abstract>
<AbstractText>The COVID-19 pandemic goes along with increased mortality from acute respiratory disease. It has been suggested that vitamin D
<sub>3</sub>
supplementation might help to reduce respiratory disease mortality. We assessed the prevalence of vitamin D insufficiency and deficiency, defined by 25-hydroxyvitamin D (25(OH)D) blood levels of 30-50 and <30 nmol/L, respectively, and their association with mortality from respiratory diseases during 15 years of follow-up in a cohort of 9548 adults aged 50-75 years from Saarland, Germany. Vitamin D insufficiency and deficiency were common (44% and 15%, respectively). Compared to those with sufficient vitamin D status, participants with vitamin D insufficiency and deficiency had strongly increased respiratory mortality, with adjusted hazard ratios (95% confidence intervals) of 2.1 (1.3-3.2) and 3.0 (1.8-5.2) overall, 4.3 (1.3-14.4) and 8.5 (2.4-30.1) among women, and 1.9 (1.1-3.2) and 2.3 (1.1-4.4) among men. Overall, 41% (95% confidence interval: 20-58%) of respiratory disease mortality was statistically attributable to vitamin D insufficiency or deficiency. Vitamin D insufficiency and deficiency are common and account for a large proportion of respiratory disease mortality in older adults, supporting the hypothesis that vitamin D
<sub>3</sub>
supplementation could be helpful to limit the burden of the COVID-19 pandemic, particularly among women.</AbstractText>
</Abstract>
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<Affiliation>Division of Clinical Epidemiology and Aging Research, Germany Cancer Research Center (DKFZ), 69118 Heidelberg, Germany.</Affiliation>
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<Affiliation>Division of Preventive Oncology, Germany Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), 69120 Heidelberg, Germany.</Affiliation>
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<Affiliation>German Cancer Consortium (DKTK), Germany Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.</Affiliation>
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